Biological, chemical, and physical hazards can put laboratory employees at risk for safety incidents that could injure themselves, fellow employees, the public, and the environment. To lower risk, each laboratory should promote a culture of safety in which laboratory safety issues are immediately addressed and consistently assessed. Laboratory employees should be trained in best practices that are outlined in the laboratory SOP and exposure control plan. These administrative controls are assessed annually or reassessed after an incident or near miss. Together these safety measures contribute to a culture of safety that helps to lower risk for laboratory employees, the public, and the environment.