The purpose of the CLIA Compliance Program (CCP) Power Hour is to connect laboratory testing personnel, general supervisors, technical supervisors, clinical consultants, and quality professionals to discuss resources, processes, and practices that support quality and compliance efforts across Infectious Disease (ID) laboratories. The CLIA Compliance Program (CCP) within the Office of Laboratory Quality provides guidance on regulatory requirements through refresher trainings, theoretical presentations, practical demonstrations, and interactive discussions on method validation and verification, quality indicators, internal and competency assessments, proficiency testing, and CLIA personnel. This session will highlight strategies for maintaining CLIA compliance and ensuring laboratories are prepared for a successful survey. Special emphasis will be placed on the importance of organized records and documentation, as effective document management is essential to demonstrating compliance, supporting quality operations, and ensuring that laboratories remain inspection-ready at all times. The overall goal of this session is to prepare CLIA laboratories for the CMS CLIA Recertification Survey and to discuss tips, tools, and best‑practice reminders for a successful survey.